#source [Melatonin as a promising agent to treat ovarian cancer: molecular mechanisms | Carcinogenesis | Oxford Academic](https://academic.oup.com/carcin/article/38/10/945/3860223?login=false) # Abstract The pharmacological and physiological properties of melatonin indicate this agent could be useful against OC progression and metastasis. In normal cells, melatonin has potent antioxidant and anti-apoptotic actions. Conversely, melatonin has pro-oxidant as well as anti-proliferative, anti-angiogenic and immunomodulatory properties in many cancer types including hormone-dependent cancers. # Conclusions In addition, melatonin exerts anticancer effects through its anti-metastatic potential, drug sensitivity restoration, apoptosis induction, growth inhibition and anti-angiogenic and anti-invasive actions Based on the evidence presented, we feel that melatonin, as an agent that controls cellular signals associated with malignancy, may be beneficial in combination with other therapeutics for OC treatment. # Matt's notes: