----- Some preclinical studies have suggested that certain antihistamines may have anti-cancer effects by inhibiting tumor growth and inducing cancer cell death. However, these findings are still in the early stages of research, and more studies are needed to determine the safety and efficacy of antihistamines, including Desloratadine, as a cancer treatment. # Matt's notes: This drug was suggested to me by a medical oncologist as one to research. I had never heard of it until he mentioned it, but it seems to have some decent results across many cancer types in trials. Seems to be a likely one to reach the mainstream at some point given its widespread and safe use as an allergy medication. Desloratadine goes by the Aerius brandname in Canada. This antihistamine works on increasing the number of several types of T cells that kill cancer cells (T cytotoxic and helper cells (Th1, th2, treg, th17)). Here is a paper that speaks about these T cells and their role in colorectal cancer: [Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer | Cancer Research | American Association for Cancer Research](https://aacrjournals.org/cancerres/article/71/4/1263/569998/Clinical-Impact-of-Different-Classes-of) This paper is a large meta-analysis of 400,000 cancer patients in Sweden and the increase in survivability for those using the antihistamines: [Improved survival in several cancers with use of H1-antihistamines desloratadine and loratadine - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868613/)