The ketogenic diet shows good marks on reducing tumor growth, reducing chemorad side effects, and improving survival rates. I'm still figuring out the best approach to using this dietary tool, but for the short term will be cycling on and off it to keep everyone 'downstairs' metabolically on their toes. I've got plenty of experience with keto, having spent the better part of 16 months in or close to full ketosis, with a net carb count of ~40 gm / day during that period. Any consideration of the ketogenic diet as it relates to cancer requires getting to know [Dom D'agostino](../../5.%20Resources/People/Dom%20D'agostino.md) and [Thomas Seyfried, Ph.D](../../5.%20Resources/People/Thomas%20Seyfried,%20Ph.D.md) and the work they've done together on their press pulse theory. #paper [Ketogenic diet in the treatment of cancer – Where do we stand? - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056920/) > In summary, 60% of the preclinical studies shown in [Table 1](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056920/table/tbl1/) reported an antitumor effect of KDs, 17% did not detect an influence on tumor growth and 10% reported adverse or pro-proliferative effects. > > Due to the capability of tumor cells to metabolize ketone bodies solely if enough oxygen is available [[120]](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056920/#bib120), tumor cells at hypoxic sites would fail to produce energy from ketone bodies even though these cells have functional mitochondria. #c-question is the rectum considered a hypoxic site? #paper [Clinical effects of ketogenic diet on recurrence of stage IV colon cancer. | Journal of Clinical Oncology](https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.15_suppl.e15709) Paper on ketogenic diet and radiation therapy: [Fasting, Fats, and Physics: Combining Ketogenic and Radiation Therapy against Cancer - Karger Publishers](https://www.karger.com/Article/FullText/484045)