[Honokiol (Magnolia officinalis)](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/magnolia-officinalis) Honokiol is one of two main actives in Magnolia (magnolol and honokiol). Magnolol demonstrated activity against a variety of cancers, including CRC. Honokiol showed antitumor and antiangiogenic effects in leukemia, lung, bladder, prostate, melanoma, breast, and other cancer cell lines. >Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma,[11] in glioblastome multiforme cells [12] and colon cancer cell lines. Honokiol inhibits phosphorylation of Akt, p44/42 mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol regulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), MCL1, and cyclooxygenase 2 (COX-2), all significant pro-angiogenic and survival factors. Honokiol also acts on the PI3K/mTOR pathway in tumor cells while maintaining pathway activity in T cells. >Source: [Honokiol - Wikipedia](https://en.wikipedia.org/wiki/Honokiol)