So many positive studies on EGCG's effects on active cancer and as a preventative focused on reducing inflammation. Seems like bioavailability is the main issue in getting high enough doses into the bloodstream. 20mg / kg of body weight used safely in a few studies. That's about 1600mg daily for me at 180 lbs. Most supps off the shelf are running 500-750mg per cap, but they vary in EGCG percentage from 50%-75% that consider that. EGCG's primary benefit is its ability to inhibit [VEGF](../../4.%20Lions%20&%20Tigers%20&%20Bears%20(Pathways%20&%20Drivers)/VEGF.md), which is a key protein involved in angiogenesis (creation of new blood vessels to a tumor). [Epigallocatechin gallate (EGCG)](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/green-tea) Works on the NOTCH signalling path. >[EGCG inhibits proliferation of colorectal cancer cells by regulating Notch signaling - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596123/) >Dosage: safely 20 mg / kg (1600 mg / day) [Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509513/) [Epigallocatechin Gallate (EGCG) Is the Most Effective Cancer Chemopreventive Polyphenol in Green Tea - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509513/)