[Citrus Bergamot (Bergamot orange)](https://en.wikipedia.org/wiki/Bergamot_orange) >Recently, statins have been proposed as new drugs to defeat CSCs, via mevalonate pathway inhibition [16]. Previous studies have shown that the modulation of this metabolic pathway is a key factor for breast CSC maintenance [17]. Statins are strong competitive inhibitors of 3-hydroxy-3-methylglutaryl-CoA-reductase enzyme (HMGR). >Some foods possess several statin-like therapeutic properties [22], possibly due to the presence of flavonoids, pectins and ascorbic acid, which have a high antioxidant potential [23], and may interfere with cholesterol and isoprene metabolism [24]. Their intake is associated with a reduced risk of numerous chronic diseases, such as cancerous processes [25]. Flavonoids also exhibit anti-viral, anti-microbial, and anti-inflammatory activities [[26], [27], [28]], and support a strong immune response [29]. In relation to that, the Bergamot fruit (Citrus bergamia Risso) has attracted attention for its remarkable flavonoid composition [[30], [31], [32]]. Recently, we detected two flavonoids (extracted from the Bergamot fruit), containing a 3-hydroxy-3-methylglutaric acid (HMG) moiety, called Brutieridin and Melitidin [33]. Their inhibitory potential against the HMGR enzyme was previously substantiated in vitro and their hypo-cholesterolemic effects were also verified in vivo [34]. >Source: [Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate - ScienceDirect](https://www.sciencedirect.com/science/article/pii/S0005272818300616?via%3Dihub)