In vitro studies have shown that this acid has strong anti-tumorigenic properties. Butyrate inhibits proliferation and induces apoptosis of CRC cell lines at physiological concentrations. Thoughts that it may mediate key processes in tumorigenesis including genomic instability, inflammation and cell energy metabolism. Apparently works well in conjunction with [Artemisinin (wormwood)](Artemisinin%20(wormwood).md). It seems most orally taken supplement versions of this acid are digested in the stomach before they reach the colon, which is where I need it, but there is a product (see below) that claims to mitigate this. Reading more on it leads me to believe this is a safe and effective supplement to be taking specific to overall gut health, which is the long-term focus. [A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate - PubMed](https://pubmed.ncbi.nlm.nih.gov/22676885/) [Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response - PubMed](https://pubmed.ncbi.nlm.nih.gov/21235278/) [Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells - PubMed](https://pubmed.ncbi.nlm.nih.gov/20346929/) From a blog post I found: >When the beneficial bacteria in your gut break down dietary fiber, they produce a short-chain fatty acid called butyric acid, also known as butyrate and butanoic acid. This fatty acid is also present in some foods, like animal fats and vegetable oils. >Short-chain fatty acids are fatty acids that come from when beneficial bacteria break down dietary fiber, and butyric acid is one of the three most common short-chain fatty acids in the gut. The two most common short-chain fatty acids are propionic acid and acetic acid. Together these three fatty acids compose up to 95% of the short-chain fatty acids in your gut. >Short-chain fatty acids like butyric acid provide colon cells with energy. Short-chain fatty acids also modulate the tissue metabolism of carbohydrates and lipids. As a result, short-chain fatty acids can improve gut health, from maintaining intestinal barrier integrity and mucus production to protecting against inflammation and preventing digestive disorders and diseases. >Source: [Butyric Acid Benefits and Butyric Acid Food List](https://www.zumanutrition.com/en-ca/blogs/health/butyric-acid-benefits-and-butyric-acid-food-list) I did find a product that claims a modified formula to overcome early digestion when taken orally: [Genestra Brands SunButyrate Liquid | Source of Butyric Acid to Support Colon Cell Energy](https://www.amazon.ca/dp/B08YYXWMZ8) Side note but interesting! Butyric acid is also produced by cheese manufacturing, and can be problematic as it produces gas and bloating the cheese product itself. Who knew? [Butyric Acid - an overview in relation to cheese | ScienceDirect Topics](https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/butyric-acid)