[Bromelain](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/bromelain) >Bromelain is an extract of pineapple and a kind of protease that has anti-inflammatory actions, fibrinolytic effects, anticancer activities, and immunomodulatory effects. The human intestines can absorb bromelain without degradation or loss of its biological properties [7]. Several studies showed that bromelain can inhibit cell growth and induce cell apoptosis in different cancers through different pathways [8–10]. In gastric cancer, bromelain treatment reduced cell growth accompanied by significant DNA perturbation. >We found that bromelain could inhibit CRC progression _in vitro_ and _in vivo_ through induction of ROS production and activation of the autophagy pathway. These findings provide new information for therapeutic applications of bromelain in CRC. >[Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy - PMC](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338369/)