[AHCC](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/ahcc) (Shiitake mushrooms) This one seems well proven and effective, even though "more studies required". It's expensive but I think worth it. Need to do more research and find the best source out there as it's expensive and I need to really bump my dosage. There are over 700 medical providers in Japan using AHCC it to treat cancer tumors. Those Japanese know their stuff; I say follow their lead. This is a product affiliate site but they are summarizing some clinical findings well, as well as talking dosages. Seems 3000 mg - 6000 mg is a safe and recommended dosage according to them: >Source: [AHCC Colon Cancer Reviews: Research, Results.](http://ahcchpv.com/ahcc-cancer/colon/) Some notes from some trial papers: >One AHCC trial enrolled 269 patients with liver cancer. Following surgery, about half of the patients took AHCC and about half did not. <mark style="background: #FFF3A3A6;">At the end of the ten-year study, only 34.5% of the AHCC patients experienced a recurrence in their cancer, compared with 66.1% of the control group that did not take AHCC. Similarly, while 46.8% of the patients in the control group had died at the end of ten years, less than half that amount - 20.4% of those in the AHCC group had.</mark> >Source: from a blog post, need to find the source study and link (Japan based) > >In this study we aimed at investigating the effects of a combination of AHCC and ETAS on colorectal cancer cells and biopsies from healthy donors to assess the possible use in patients with colorectal cancer. Our results showed that the combination of AHCC and ETAS was synergistic in inducing a significant decrease in cancer cell growth, compared with single agents. Moreover, the combined treatment induced a significant increase in apoptosis, sparing colonocytes from healthy donors, and was able to induce a strong reduction in migration potential, accompanied by a significant modulation of proteins involved in invasiveness. >Source: [Combination of AHCC and ETAS Decreases Migration of Colorectal Cancer Cells, and Reduces the Expression of LGR5 and Notch1 Genes in Cancer Stem Cells](https://www.researchgate.net/publication/357180946_The_Combination_of_AHCC_and_ETAS_Decreases_Migration_of_Colorectal_Cancer_Cells_and_Reduces_the_Expression_of_LGR5_and_Notch1_Genes_in_Cancer_Stem_Cells_A_Novel_Potential_Approach_for_Integrative_Medi)